Table 2 Simulation study of observed type I error (%) for general linear models using anti-CCP titer as outcome (Tests N = 1,000,000 random genotypes)
Expected α level | |||||
|---|---|---|---|---|---|
MAF | 0.01 | 0.001 | 0.0001 | 0.00001 | 0.000001 |
0.01 | 0.0086 | 0.00006 | 0.00007 | 0.0000160 | 0.0000008 |
0.05 | 0.0097 | 0.00009 | 0.00009 | 0.0000104 | 0 |
0.1 | 0.0098 | 0.00106 | 0.00012 | 0.0000160 | 0.0000040 |
0.2 | 0.0010 | 0.00096 | 0.00010 | 0.0000098 | 0.0000020 |
0.3 | 0.0101 | 0.00101 | 0.00011 | 0.0000093 | 0.0000021 |
0.4 | 0.0099 | 0.0010 | 0.00011 | 0.0000134 | 0 |
0.5 | 0.0100 | 0.0010 | 0.00011 | 0.000014 | 0 |