Genome-Wide Association Study of Determinants of Anti-Cyclic Citrullinated Peptide Antibody Titer in Adults with Rheumatoid Arthritis

Cui, Jing; Taylor, Kimberly E.; DeStefano, Anita L.; Criswell, Lindsey A.; Izmailova, Elena S.; Parker, Alex; Roubenoff, Ronenn; Plenge, Robert M.; Weinblatt, Michael E.; Shadick, Nancy A.; Karlson, Elizabeth W.

doi:10.2119/molmed.2009.00008

Molecular Medicine

Table 3 Top 25 most significant associations between SNPs and anti-CCP titer using general linear models for BRASS and NARAC

From: Genome-Wide Association Study of Determinants of Anti-Cyclic Citrullinated Peptide Antibody Titer in Adults with Rheumatoid Arthritis

Chr	100K RS number	Physical location	Gene	BRASS				NARAC
Chr	100K RS number	Physical location	Gene	P value^a from GLM	P value^b	MAF	Call Rate	550K RS number^c	LD R²	P
6	rs2001097	32491836	HLA-DRA	3.88E-07	0.0036	0.132	0.970	rs1980493	0.85	6.1E-05
6	rs2395167	32496286	BTNL2	5.95E-07	0.0034	0.131	0.987	rs1980493	0.85	6.1E-05
6	rs2213580	32496552	HLA-DRA	9.04E-07	0.0038	0.132	1	rs1980493	0.85	6.1E-05
6	rs2001099	32491611	BTNL2	9.78E-07	0.005	0.134	0.998	rs1980493	0.85	6.1E-05
6	rs1041885	32520787	HLA-DRA	1.07E-06	0.0027	0.134	0.996	rs1980493	0.85	6.1E-05
21	rs2837108	39953480	C21orf8	9.72E-06	0.0017	0.473	0.992	rs2837108	1	0.8693
18	rs1147760	32654700	C18orf1	2.1E-05	0.0026	0.136	0.996	rs13313604	0.908	0.9207
18	rs10502668	32756590	KIAA132	2.55E-05	0.0025	0.13	0.996	rs10502668	1	0.9406
8	rs2945913	8235635	—	4.11E-05	0.0013	0.151	0.981	rs2945913	1	0.1276
5	rs2112342	116261135	—	4.34E-05	0.0026	0.368	0.998	rs2112342	1	0.2793
18	rs1445527	32769877	KIAA132	4.93E-05	0.002	0.132	0.983	rs13313604	1	0.9207
18	rs2017027	33059192	KIAA132	5.07E-05	0.004	0.13	0.996	rs13313604	0.81	0.9207
9	rs4877406	87990359	SPIN	6.32E-05	0.0005	0.276	0.964	rs4877406	1	0.9854
4	rs842873	73061500	GPR74	7.78E-05	0.0007	0.44	1	—^c
6	rs10484713	140662577	—	0.000104	0.0146	0.255	0.977	rs10457702	1	0.6854
18	rs10502669	32758505	KIAA132	0.000106	0.0052	0.132	0.994	rs13313604	1	0.9207
5	rs10514299	87699366	MGC3321	0.000116	0.021	0.239	1	rs10514299	1	0.4791
6	rs5000563	32512113	HLA-DRA	0.000128	0.028	0.254	0.994	rs2395174	1	0.883
6	rs1357056	122405433	GJA1	0.00014	0.0044	0.063	0.998	rs2684265	1	0.5603
11	rs313877	102830195	DDI1	0.000141	0.0132	0.194	0.985	rs1481980	0.958	0.1932
5	rs2056403	52399256	ITGA2	0.000156	0.0026	0.257	0.983	rs1421933	1	0.7621
5	rs390856	87583315	MGC3321	0.000165	0.0215	0.241	0.998	rs10514299	1	0.4791
3	rs10510617	28989642	RBMS3	0.000174	0.0017	0.48	1	rs6768946	0.869	0.07224
4	rs1246590	75463744	—	0.000182	0.0084	0.252	0.981	rs1265327	1	0.6153
6	rs6922541	135524512	HBS1L	0.000189	0.0034	0.404	0.981	rs6922541	1	0.4497

^aP value from GLM using all BRASS subjects, N = 531.
^bP value from GLM using only CCP+ subjects, N = 401.
^c550K entries did not have a tagging SNP on 550K genotyping platform.

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ISSN: 1528-3658

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