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Figure 1 | Molecular Medicine

Figure 1

From: Persistent Fetal γ-Globin Expression in Adult Transgenic Mice following Deletion of Two Silencer Elements Located 3′ to the Human Aγ-Globin Gene

Figure 1

Schematic presentation of the constructs used in this study. (A) Control construct containing the LCR linked to the 5.6 kb Aγ-gene including both Enh and F elements. (B) ΔEnh/F construct containing the LCR linked to the 3.3 kb Aγ-gene lacking Enh and F elements. A diagram of the human β-globin locus is shown on the top of the panel, depicting the five functional globin genes and the four silencer elements Enh, F, O, and P.The vertical arrows denote the five major DNasel hypersensitive sites of the LCR.

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Molecular Medicine

ISSN: 1528-3658