Short-Term Overeating Induces Insulin Resistance in Fat Cells in Lean Human Subjects

Table 1 Characteristics of subjects participating in the high-calorie diet.^a

	BMI,kg/m²		Total body fat, kg		Insulin, pmol/L		HOMA		QUICKI
Age, years	Baseline	End	Baseline	End	Baseline	End	Baseline	End	Baseline	End
27.3 ± 3.2	22.4 ± 1.8	24.3 ± 2.2	17.6 ± 6.0	21.0 ± 6.7	36.7 ± 15.9	50.3 ± 17.9	1.1 ± 0.5	1.6 ± 0.6	0.385 ± 0.056	0.356 ± 0.038
	P = 0.002		P = 0.006		P = 0.030		P = 0.036		P = 0.029

^aValues are the average for the participating subjects at the start of the study (baseline) and at the end, or the ratio of the averages for the values at the end and at baseline, means ± SD (n = 6), P from paired Student ttest. Body composition was determined by dual energy x-ray absorptiometry (Hologic 4500, Hologic). BMI, body mass index; HOMA, homeostasis model assessment (30); QUICKI, quantitative insulin sensitivity check index (31).

ISSN: 1528-3658