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Table 1 Genomic regions with variants likely to contribute to individual differences in smoking cessation success based on data from the current study. The data highlight the same small chromosomal regions identified by clustered nominally positive SNPs from at least one other GWA study of ability to quit smoking or of vulnerability to dependence on addictive substances.

From: Genome-Wide Association for Smoking Cessation Success: Participants in a Trial with Adjunctive Denicotinized Cigarettes

chra

bp:start

bp:endb

# SNPsc

Confirm sampled

# Confirm SNPse

Genesf

1

29,920,187

29,948,179

4

C

2g

 

1

167,937,772

167,975,898

5

E

4

SELL, SELE h

2

9,192,143

9,207,808

7

E

6

 

2

100,649,980

100,682,660

9

C

3

 

2

139,403,085

139,450,494

4

B

2

 

2

221,891,738

221,913,606

9

E

4

 

2

224,903,889

224,953,132

7

F

2

FLJ22746

2

231,987,255

232,009,914

5

F

1

 

3

10,972,362

10,995,033

9

C

2

 

3

35,749,993

35,762,465

5

E

4

ARPP-21 J , MIRN128B

3

38,734,469

38,778,513

4

B

3

SCN10A

3

141,216,152

141,287,770

7

B

3

CLSTN2j

3

141,800,311

141,835,923

4

A

9

 

3

141,800,311

141,835,923

4

F

1

 

3

144,085,356

144,113,673

4

E

16

PCOLCE2

3

146,729,297

146,774,561

7

A

3

 

4

41,672,864

41,833,889

4

E

16

ATP1BL1, CCD4, SLC30A9 k

4

126,093,238

126,113,552

6

D, E

4,4

 

4

126,193,075

126,232,652

4

D

4

 

4

168,191,419

168,193,048

4

C

3

SPOCK3k

5

168,177,383

168,207,535

5

C

3

SLIT3

6

86,706,424

86,761,974

6

E

5

 

6

98,227,102

98,268,675

5

E

4

 

6

105,161,737

105,193,915

4

B

2

 

6

144,960,512

144,982,008

4

C

2

UTRN

7

42,471,602

42,487,544

4

E

8

 

8

3,909,332

3,944,372

4

C,D,E

3,6,9

CSMD1

9

89,373,187

89,380,485

4

B

3

DAPK1

9

102,617,616

102,659,836

6

E

12

 

9

102,809,194

102,826,144

6

F

1

PRG-3

10

2,734,009

2,811,707

8

B

2

k

10

49,758,250

49,810,114

6

A,B

4,8

LRRC18k

10

49,758,250

49,810,114

6

F

1

 

10

66,303,948

66,409,111

13

E

7

 

10

69,720,623

69,731,358

4

D

4

MAWBP

10

88,086,066

88,108,932

5

F

3

GRID1

10

108,879,748

108,964,249

9

B,C

3,2

SORCS1

10

118,957,450

118,976,703

4

B

4

KCNK18k

11

81,985,443

82,024,265

4

B,E

3,4

 

11

91,649,044

91,675,441

4

E

4

 

11

108,260,231

108,310,082

7

E

4

DDX10

11

117,090,924

117,119,023

4

C

2

DSCAML1k

12

221,728

248,990

5

B

2

SLC6A13k

12

3,432,200

3,452,279

4

F

1

 

12

32,976,465

33,009,217

7

C,F

2,1

 

12

33,039,131

33,072,493

6

C

2

 

12

104,124,882

104,149,349

4

D

3

APPL2

12

115,255,355

115,276,560

4

F

1

 

13

33,740,610

33,765,548

4

C

2

 

13

44,202,415

44,209,971

4

C

2

 

13

60,112,584

60,160,245

15

E

6

k

13

61,658,287

61,687,708

4

F

1

 

14

102,690,084

102,714,789

5

E

5

RPL21P12

15

24,857,276

24,876,109

4

C

2

 

16

4,508,770

4,534,672

4

B

2

C16 or f5, HMOX2k

16

80,978,225

81,035,927

6

A

3

 

17

47,051,861

47,087,703

4

B

2

CA10j

18

4,636,261

4,670,052

4

A

6

 

18

10,027,213

10,030,445

5

C

4

k

18

54,104,584

54,136,429

4

E

5

NEDD4L

20

17,715,035

17,728,921

6

B

4

 

20

41,966,838

41,982,230

4

A

4

C20 or f100

20

53,283,389

53,307,708

5

B,D

2,5

k

21

32,721,019

32,799,427

9

A

3

C21 or f63

22

48,374,819

48,392,082

4

B

2

C22 or f34

  1. aChromosome for the genomic region identified by clustered nominally positive SNPs from the current study and supporting data from at least one other study.
  2. bBasepair coordinates for the beginning and end of the genomic region.
  3. cNumber of nominally positive SNPs that lay in clusters within the region in the current sample
  4. dCode for the confirmatory sample(s): A, Lerman; B, Brown; C, Rose from (8); D, Hamer (9); E, data from European-American samples from comparisons of substance dependent to control samples (Drgon submitted); and F, data from comparison of 38,000 SNPs from (12).
  5. eNumber of SNPs in the confirmatory sample that fall into the chromosomal region defined by the current sample.
  6. fAnnotated gene(s) that fall within the chromosomal region, if any.
  7. gBoldfaced segments are those identified by data from at least two smoking cessation studies.
  8. htalicized segments are those identified by data from the current smoking cessation study and at least one addiction vulnerability GWA sample.
  9. iGenes for which “NRT-selective” effects have been previously suggested in eTable 4 in (8).
  10. kGenes (or chromosomal regions) for which some (but not all) of the nominally positive SNPs fall into the group of SNPs with the 2.5% largest differences between control European American versus African American research volunteers in prior studies (C Johnson, T Drgon, and GR Uhl, unpublished observations, 2008).
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Molecular Medicine

ISSN: 1528-3658