Figure 2

Tissue protective compounds improve wound healing in a raised skin flap (permanent ischemia) model. Both treated and untreated rats with a permanently ischemic, caudally based cutaneous flap exhibited a large necrotic wound area that took more than 5 wks to fully heal. (A) At 35 d following injury, wounds in the saline group were significantly larger (P< 0.05) than the group that received CEPO (30 µg/kg twice weekly intraperitoneally). (B) Representative examples of wound size from both treatment groups. Notably, wounds in the saline group healed by transverse constriction which was not apparent in CEPO group.