Figure 1

Spermine protected mice against lethal sepsis. Balb/C mice were subjected to lethal sepsis (induced by CLP), and spermine was administered intraperitoneally (i.p., 10 mg/kg, twice a day, for 3 d) beginning at +24 h (A) or +0.5 h (B) post the onset of sepsis. The Kaplan-Meier method was used to compare mortality rates between groups of two independent experiments (with 13–14 mice per group) with similar results. Arrows indicate the time points of spermine administration. ^*P< 0.05 versus saline control group.