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Table 1 Effects of sham vagotomy or vagotomy on serum levels of AST, ALT, LDH, lactate, and creatinine in sham operated animals (Sham) and septic animals treated with normal saline (Vehicle) or ghrelin (Ghrelin) at 20 h after radiation combined injury (RCI).

From: Human Ghrelin Ameliorates Organ Injury and Improves Survival after Radiation Injury Combined with Severe Sepsis

  

Sham

RCI-Vehicle

RCI-Ghrelin

AST (IU/L)

Sham vagotomy

30 ± 2.4a

139 ± 6.0b

70 ± 5.0bc

 

Vagotomy

35 ± 1.4

166 ± 8.0b

166 ± 7.0b

ALT (IU/L)

Sham vagotomy

18 ± 0.9

79 ± 3.3b

42 ± 2.1bc

 

Vagotomy

18 ± 1.0

78 ± 2.9b

75 ± 2.9b

LDH (U/L)

Sham vagotomy

561±60.3

2526 ± 145.3b

1092 ± 88.5bc

 

Vagotomy

601 ± 36.7

2403 ± 176.6b

2198 ± 172.0b

Lactate (mg/dl)

Sham vagotomy

14 ± 1.4

30 ± 2.8b

22 ± 1.2bc

 

Vagotomy

16 ± 1.0

30 ± 2.4b

29 ± 2.3b

Creatinine (mmol/L)

Sham vagotomy

0.5 ± 0.03

2.5 ± 0.28b

1.6 ± 0.18bc

 

Vagotomy

0.6 ± 0.07

2.6 ± 0.21b

2.7 ± 0.09b

  1. aData are presented as means ± SE (n = 6/group) and compared by ANOVA and Student-Newman-Keuls method.
  2. bP < 0.05 versus respective Sham group.
  3. cP < 0.05 versus respective Vehicle group.