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Table 2 Effects of sham vagotomy or vagotomy on serum levels of TNF-α, IL-6, as well as myeloperoxidase (MPO) activities in the intestine, lungs and kidneys in sham operated animals (Sham) and septic animals treated with normal saline (Vehicle) or ghrelin (Ghrelin) at 20 h after radiation combined injury (RCI).

From: Human Ghrelin Ameliorates Organ Injury and Improves Survival after Radiation Injury Combined with Severe Sepsis

  

Sham

RCI-Vehicle

RCI-Ghrelin

TNF-α (pg/mL)

Sham vagotomy

46 ± 9.0a

83 ± 5.6b

53 ± 4.2bc

 

Vagotomy

51 ± 6.7

83 ± 4.4b

78 ± 4.5b

IL-6 (pg/mL)

Sham vagotomy

41 ± 1.9

1507 ± 120.1b

670 ± 64.0bc

 

Vagotomy

37 ± 4.2

1335 ± 85.3b

1417 ± 109.6b

Intestinal MPO (µU/mg)

Sham vagotomy

1.2 ± 0.08

28.1 ± 3.27b

14.6 ± 1.08bc

 

Vagotomy

1.2 ± 0.13

29.9 ± 2.90b

31.0 ± 1.96b

Pulmonary MPO (µU/mg)

Sham vagotomy

1.0 ± 0.14

23.3 ± 2.03b

15.1 ± 1.34bc

 

Vagotomy

1.3 ± 0.14

24.9 ± 2.49b

23.9 ± 2.41b

Renal MPO (µU/mg)

Sham vagotomy

1.8 ± 0.21

11.4 ± 0.86b

5.5 ± 0.58bc

 

Vagotomy

1.6 ± 0.27

10.3 ± 0.95b

11.5 ± 1.39b

  1. aData are presented as means ± SE (n = 6/group) and compared by one-way analysis of variance (ANOVA) and Student-Newman-Keuls method.
  2. bP ± 0.05 versus respective Sham group.
  3. cP < 0.05 versus respective Vehicle group.