Figure 1

MIF immunostain in association with amyloid plaques. Serial section of plaque bearing APP 23 mice were stained for amyloid deposits (A) and for MIF proteins (B) using the mentioned antibodies in the appropriate dilution. The overlay (C) of both photographs displays the plaque dependent MIF staining (arrows indicate the MIF positive cells, P: plaque). A similar staining pattern was obtained in a total of eight sections from four different transgenic APP mice.