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Figure 2 | Molecular Medicine

Figure 2

From: MTHFR, MTR, and MTRR Polymorphisms in Relation to p16INK4A Hypermethylation in Mucosa of Patients with Colorectal Cancer

Figure 2

Multivariate Cox model showing cancer-specific survival of stage I–III patients subgrouped according to MTRR genotypes and dichotomized p16 hypermethylation status in mucosa. (A) As shown, patients with the MTRR 66 AA/AG genotypes had a significantly worse survival (P = 0.023) when the mucosa was positive for p16 hypermethylation (n = 59) compared with when the mucosa was negative for p16 hypermethylation (n = 30). (B) In contrast, there was no difference in survival among patients with the MTRR 66 GG genotype stratified by p16 hypermethylation status (P= .55; n = 24 and n = 16 in respective groups).

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Molecular Medicine

ISSN: 1528-3658