Table 3 Organ Gb3a levels 26 weeks postinjection (Experiment 2)
From: α-Galactosidase A-Tat Fusion Enhances Storage Reduction in Hearts and Kidneys of Fabry Mice
Gb3 levels (nmol/mg protein) | |||||
|---|---|---|---|---|---|
Liver | Spleen | Heart | Kidney | Lung | |
LV/enGFP | 20.9 ± 2.9 (n = 7) | 63.2 ± 1.8 (n = 6) | 17.0 ± 1.4 (n = 6) | 37.0 ± 3.0 (n = 5) | 48.0 ± 0.7 (n = 6) |
LV/α-gal A | 7.5 ± 1.1 (n = 6) | 34.0 ± 2.8 (n = 6) | 15.8 ± 2.0 (n = 6) | 30.2 ± 1.3 (n = 5) | 44.1 ± 3.4 (n = 4) |
LV/α-gal A-Tat | 1.9 ± 0.3b (n = 8) | 29.8 ± 2.0 (n = 7) | 10.0 ± 0.8c (n = 6) | 30.3 ± 1.9 (n = 5) | 47.5 ± 2.9 (n = 7) |