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Table 3 Organ Gb3a levels 26 weeks postinjection (Experiment 2)

From: α-Galactosidase A-Tat Fusion Enhances Storage Reduction in Hearts and Kidneys of Fabry Mice

Gb3 levels (nmol/mg protein)
  Liver Spleen Heart Kidney Lung
LV/enGFP 20.9 ± 2.9 (n = 7) 63.2 ± 1.8 (n = 6) 17.0 ± 1.4 (n = 6) 37.0 ± 3.0 (n = 5) 48.0 ± 0.7 (n = 6)
LV/α-gal A 7.5 ± 1.1 (n = 6) 34.0 ± 2.8 (n = 6) 15.8 ± 2.0 (n = 6) 30.2 ± 1.3 (n = 5) 44.1 ± 3.4 (n = 4)
LV/α-gal A-Tat 1.9 ± 0.3b (n = 8) 29.8 ± 2.0 (n = 7) 10.0 ± 0.8c (n = 6) 30.3 ± 1.9 (n = 5) 47.5 ± 2.9 (n = 7)
  1. aGb3, globotriaosylceramide.
  2. bP < 0.01 vs LV/α-gal A group.
  3. cP < 0.05.