Figure 2

(A) Identification of an exercise-induced gene network involved in tissue inflammation using the Ingenuity Pathways Analysis knowledge database. Several genes regulated by TNFα were negatively modulated by resistance exercise, suggesting that they may play a role in the antiinflammatory effects of exercise in myositis patients (see text for further explanations). (B) Model of exercise-induced reduction in inflammation in autoimmune myositis patients. Based on the experimental expression data generated by the microarray analysis, we developed a hypothetical model in which three discrete steps in the regulation of tissue inflammation can be identified, suggesting that exercise could reduce inflammation by downregulating the expression of genes involved in activation and proliferation of T-cells and macrophages, migration and adhesion. (Panel A image: © 2000–2010 Ingenuity Systems, Inc. All rights reserved.)