Table 1 Exercise effects on gene expression (selected genes).
Gene symbol | Gene name | Affymetrix ID | Fold-change | P |
|---|---|---|---|---|
Inflammation genes | ||||
ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | 221421_s_at | −1.6 | 0.037 |
ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 (aggrecanase-2) | 219935_at | −1.5 | 0.015 |
C1S | Complement component 1, s subcomponent | 208747_s_at | −1.5 | 0.036 |
CBL | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 225231_at | −1.6 | 0.003 |
CBLB | Cas-Br-M (murine) ecotropic retroviral transforming sequence b | 233614_at | −1.6 | 0.022 |
CCL14 | Chemokine (C-C motif) ligand 14 | 205392_s_at | −2.1 | 0.022 |
CCR1 | Chemokine (C-C motif) receptor 1 | 205098_at | −1.8 | 0.007 |
CD200 | CD200 antigen | 209583_s_at | −1.6 | 0.012 |
CD226 | CD226 antigen | 207315_at | 1.7 | 0.042 |
CD244 | CD244 natural killer cell receptor 2B4 | 234320_at | 2.9 | 0.02 |
CD44 | CD44 antigen (Indian blood group) | 1565868_at | −1.6 | 0.05 |
CD81 | CD81 antigen (target of antiproliferative antibody 1) | 200675_at | −1.5 | 0.02 |
CHL1 | Cell adhesion molecule with homology to L1CAM (close homolog of L1) | 204591_at | −1.9 | 0.017 |
CHST3 | Carbohydrate (chondroitin 6) sulfotransferase 3 | 209834_at | −1.5 | 0.031 |
CLU | Clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) | 208791_at | −1.7 | 0.03 |
CSF2RB | Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | 205159_at | −1.6 | 0.035 |
DOCK2 | Dedicator of cytokinesis 2 | 213160_at | −2.3 | 0.013 |
FOXP3 | Forkhead box P3 | 221334_s_at | 2.2 | 0.033 |
HDAC2 | Histone deacetylase 2 | 242141_at | −2.4 | 0.045 |
HLA-F | Major histocompatibility complex, class I, F | 221978_at | −1.6 | 0.01 |
IL10RB | Interleukin 10 receptor, beta | 209575_at | −1.5 | 0.007 |
IL2RG | Interleukin 2 receptor, γ (severe combined immunodeficiency) | 204116_at | −1.5 | 0.027 |
IRAK3 | Interleukin-1 receptor-associated kinase 3 | 1568830_at | −1.9 | 0.009 |
KLF4 | Kruppel-like factor 4 (gut) | 221841_s_at | −1.8 | 0.006 |
LITAF | Lipopolysaccharide-induced TNF factor | 200706_s_at | −2.3 | 0.002 |
NLK | Nemo-like kinase | 238624_at | −2.2 | 0.018 |
NPY2R | Neuropeptide Y receptor Y2 | 210730_s_at | 2.1 | 0.019 |
OPRK1 | Opioid receptor, kappa 1 | 229944_at | −3.3 | 0.023 |
PAG | Phosphoprotein associated with glycosphingolipid microdomains 1 | 225622_at | −1.5 | 0.016 |
PELI2 | Pellino homolog 2 (Drosophila) | 219132_at | −1.7 | 0.028 |
PRTN3 | Proteinase 3 (serine proteinase, neutrophil, Wegener granulomatosis autoantigen) | 207341_at | 2.2 | 0.01 |
PTGS1/COX1 | Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 238669_at | −1.7 | 0.019 |
REL | v-rel Reticuloendotheliosis viral oncogene homolog (avian) | 206035_at | −1.7 | 0.035 |
RFX2 | Regulatory factor X, 2 (influences HLA class II expression) | 240156_at | −1.7 | 0.028 |
RFX3 | Regulatory factor X, 3 (influences HLA class II expression) | 240867_at | 1.7 | 0.027 |
RTKN | Rhotekin | 225150_s_at | −2.1 | 0.04 |
S100A13 | S100 calcium binding protein A13 | 213481_at | −2 | 0.048 |
SEMA4D | Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | 1562250_at | 2.4 | 0.05 |
TCIRG1 | T-cell, immune regulator 1, ATPase, H + transporting, lysosomal V0 protein A3 | 204158_s_at | −2.3 | 0.048 |
TLR8 | Toll-like receptor 8 | 229560_at | −1.5 | 0.049 |
VAV1 | Vav 1 oncogene | 206219_s_at | −3.5 | 0.031 |
Fibrosis genes | ||||
ADAM12 | ADAM metallopeptidase domain 12 (meltrin alpha) | 226777_at | −3.7 | 0.004 |
FBN2 | Fibrillin 2 (congenital contractural arachnodactyly) | 203184_at | −3.2 | 0.014 |
VIM | Vimentin | 1555938_x_at | −3.1 | 0.045 |
MGP | Matrix Gla protein | 238481_at | −2.6 | 0.012 |
HGF | Hepatocyte growth factor (hepapoietin A; scatter factor) | 210755_at | −2.3 | 0.045 |
EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 225275_at | −2.3 | 0.01 |
COMP | Cartilage oligomeric matrix protein | 205713_s_at | −2.1 | 0.049 |
CHRD | Chordin | 211248_s_at | −2.1 | 0.029 |
CALCRL | Calcitonin receptor-like | 234996_at | −2 | 0.004 |
FGF1 | Fibroblast growth factor 1 (acidic) | 205117_at | −2 | 0.016 |
COL14A1 | Collagen, type XIV, α 1 (undulin) | 212865_s_at | −1.8 | 0.031 |
COL1A1 | Collagen, type I, α 1 | 1556499_s_at | −1.7 | 0.04 |
PLOD2 | Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 202620_s_at | −1.7 | 0.04 |
MAOA | Monoamine oxidase A | 212741_at | −1.6 | 0.022 |
LRRFIP1 | Leucine rich repeat (in FLII) interacting protein 1 | 227391_x_at | −1.6 | 0.001 |
NCAM1 | Neural cell adhesion molecule 1 | 212843_at | −1.6 | 0.034 |
LOXL1 | Lysyl oxidase-like 1 | 203570_at | −1.6 | 0.045 |
CSPG2 | Chondroitin sulfate proteoglycan 2 (versican) | 204619_s_at | −1.6 | 0.015 |
CTGF | Connective tissue growth factor | 209101_at | −1.6 | 0.022 |
NID | Nidogen 1 | 202007_at | −1.5 | 0.021 |
COL5A2 | Collagen, type V, α 2 | 221729_at | −1.5 | 0.046 |
MFAP4 | Microfbrillar-associated protein 4 | 212713_at | −1.5 | 0.022 |
LTBP1 | Latent transforming growth factor β binding protein 1 | 1566267_at | 1.5 | 0.034 |
PREP | Prolyl endopeptidase | 229644_at | 1.7 | 0.038 |
MMP16 | Matrix metallopeptidase 16 (membrane-inserted) | 208166_at | 2.7 | 0.041 |
Metabolism genes | ||||
ALDH1L1 | Aldehyde dehydrogenase 1 family member L1 | 1559766_at | −2.6 | 0.008 |
AK3 | Adenylate kinase 3-like 1 | 230630_at | −2.3 | 0.039 |
ACACA | Acetyl-coenzyme A carboxylase alpha | 212186_at | −1.5 | 0.046 |
ATP2C1 | ATPase, Ca ++ transporting, type 2C, member 1 | 209935_at | −1.5 | 0.02 |
UCP3 | Uncoupling protein 3 (mitochondrial, proton carrier) | 219827_at | 1.6 | 0.005 |
UQCRC2 | Ubiquinol-cytochrome c reductase core protein II | 239465_at | 1.6 | 0.039 |
ATP1B2 | ATPase, Na+/K+ transporting, β2 polypeptide | 204311_at | 1.8 | 0.025 |