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Figure 1 | Molecular Medicine

Figure 1

From: Peroxynitrite-induced Nitration of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Promotes Their Binding in Diabetic Angiopathy

Figure 1

Pathological changes in the aortic endothelium of diabetic rat. (A) HE staining of the aorta in different groups (×400). The intact endothelium was seen in the control group, the endothelium was falling in the diabetes group and only part of the endothelium was falling in the diabetes + urate group (the black arrow indicates endothelial cells). (B) Ultrastructure of the endothelial cell under a TEM (40,000-fold). An endothelial cell with numerous pinocytosis vesicles (indicated by the black arrow) and intact mitochondria was observed in the control group. However, the endothelial cell was damaged severely in the diabetes group. In the diabetes + urate group, mitochondrial damages attenuated, and only parts of the cell junction were fused in the endothelial cell (red arrows indicate mitochondrium and blue arrows indicate cell junction).

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Molecular Medicine

ISSN: 1528-3658