Peroxynitrite-induced Nitration of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Promotes Their Binding in Diabetic Angiopathy

Table 1 Changes of body weight, blood glucose and activity of COX-2 and iNOS.

Group	Body weight (g)	Blood glucose (mmol/L)	Activity of COX-2 in serum (U/mL)	Activity of iNOS in serum (U/mL)
Control	521 ± 81	6.05 ± 0.94	8.32 ± 2.36	15.32 ± 1.25
Diabetes	347 ± 43^a	22.20 ± 5.57^a	35.02 ± 3.15^a	30.80 ± 1.88^a
Diabetes + urate	320 ± 61	18.88 ± 3.21	14.41 ± 3.79^b	22.25 ± 1.87^b

After 13 wks, body weight, fasting blood glucose and the activity of COX-2 and iNOS were measured. Data were presented as means ± SD (n = 8 in each group).
^aP < 0.01 compared with the control group.
^bP < 0.01 compared with the diabetes group.

ISSN: 1528-3658