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Table 2 Changes of endothelial and glomerular damage.

From: Peroxynitrite-induced Nitration of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase Promotes Their Binding in Diabetic Angiopathy

Group

Ratio of EC (%)

Glomerular area (µm2)

Thickness of GBM (nm)

Control

100.0

15.8 ± 0.4

118.0 ± 2.1

Diabetes

7.5

21.6 ± 0.5a

194.2 ± 24.5a

Diabetes + urate

65.1

18.9 ± 0.4b

143.7 ± 6.9b

  1. After 13 wks, the ratio of endothelial cell (EC) and glomerular area in HE staining (×400) and thickness of glomerular basement membrane (GBM) under a TEM (×20K) were measured. Data were presented as means ± SD.
  2. aP < 0.01 compared with the control group.
  3. bP < 0.01 compared with the diabetes group.
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Molecular Medicine

ISSN: 1528-3658