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Table 3 Enzyme activities in erythrocytes of the affected proband and WT cats.

From: Feline Congenital Erythropoietic Porphyria: Two Homozygous UROS Missense Mutations Cause the Enzyme Deficiency and Porphyrin Accumulation

Enzyme

WT, U/mg protein, (n)a (range)

Wisconsin (n = 1)

U/mg protein (n)a

% of WT

HMB-synthase

0.017 (3) (0.015–0.021)

0.056 (1)

330

URO-synthase

0.54 (1) (0.43–0.62)b

0.0036 (2)

0.67

  1. aExpressed purified WT activity: 1 U = nmol product/h/mg protein.
  2. bRange for 5 replicates.
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Molecular Medicine

ISSN: 1528-3658