Feline Congenital Erythropoietic Porphyria: Two Homozygous UROS Missense Mutations Cause the Enzyme Deficiency and Porphyrin Accumulation

Table 5 Characteristics of feline AIP and CEP

Feature	Feline AIP	Feline CEP
Brownish teeth (erythodontia) that fluoresce	+	+
Inheritance	Autosomal dominant	Autosomal recessive
HMB-synthase activity	Half-normal	Normal
URO-synthase activity	Normal or increased	<1%
Urinary ALA	Normal or slightly increased	Normal
Urinary PBG	Increased 3-13-fold	Normal
Urinary URO I	Increased 240-fold	Increased 2,700-fold
Urinary URO III	Increased 220-fold	Increased 190-fold
Erythrocyte III isomer,^a %	65%	0.9%
Urine III isomer, %	31%	3.4%

ISSN: 1528-3658