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Table 2 Univariate analysis between APOE/C1/C2/C4 genotypes and lipid traits.

From: APOE/C1/C4/C2 Gene Cluster Genotypes, Haplotypes and Lipid Levels in Prospective Coronary Heart Disease Risk Among UK Healthy Men

  

LDL-C

apoB

Averagea TG

HDL-C

ApoAI

  

nb

Mean (SE)c

n

Mean (SE)

n

Mean (SE)

n

Mean (SE)

n

Mean (SE)

ApoE

2+d

368

2.69 (0.05)

368

0.77 (0.01)

429

1.91 (0.02)

365

1.71 (0.03)

368

1.65 (0.02)

 

33

1,356

3.13 (0.03)

1,358

0.87 (0.01)

1,580

1.81 (0.01)

1,347

1.72 (0.02)

1,358

1.64 (0.01)

 

4+e

581

3.26 (0.04)f

582

0.90 (0.01)f

696

1.88 (0.02)g

579

1.66 (0.02)

582

1.61 (0.01)

rs405509

11

622

3.00 (0.04)

623

0.84 (0.01)

724

1.88 (0.02)

614

1.71 (0.02)

623

1.64 (0.01)

 

12

1,242

3.09 (0.03)

1,244

0.86 (0.01)

1,471

1.83 (0.01)

1,235

1.70 (0.02)

1,244

1.63 (0.01)

 

22

492

3.21 (0.04)f

492

0.89 (0.01)f

567

1.83 (0.02)

491

1.70 (0.03)

492

1.63 (0.01)

rs439401

11

998

3.11 (0.03)

1,000

0.86 (0.01)

1,176

1.88 (0.01)

988

1.68 (0.02)

1,000

1.62 (0.01)

 

12

1,090

3.06 (0.03)

1,090

0.86 (0.01)

1,281

1.83 (0.01)

1,084

1.71 (0.02)

1,090

1.64 (0.01)

 

22

268

3.16 (0.06)

269

0.88 (0.02)

305

1.77 (0.03)

268

1.76 (0.04)

269

1.66 (0.02)

rs4420638

11

1,575

3.03 (0.02)

1,576

0.85 (0.01)

1,834

1.82 (0.01)

1,565

1.72 (0.01)

1,576

1.64 (0.01)

 

12

696

3.18 (0.04)

698

0.88 (0.01)

823

1.89 (0.02)

690

1.68 (0.02)

698

1.62 (0.01)

 

22

85

3.56 (0.11)f

85

0.96 (0.03)f

105

1.94 (0.04)

85

1.66 (0.06)

85

1.61 (0.03)

rs4803770

11

835

3.06 (0.03)

836

0.85 (0.01)

963

1.84 (0.01)

832

1.75 (0.02)

836

1.65 (0.01)

 

12

1,239

3.09 (0.03)

1,241

0.86 (0.01)

1,472

1.85 (0.01)

1,229

1.68 (0.02)

1,241

1.62 (0.01)

 

22

282

3.23 (0.06)g

282

0.90 (0.02)f

327

1.84 (0.02)

279

1.68 (0.03)g

282

1.61 (0.02)

rs7259004

11

1,914

3.13 (0.02)

1,917

0.87 (0.01)

2,252

1.85 (0.01)

1,901

1.69 (0.01)

1,917

1.62 (0.01)

 

12

420

2.96 (0.05)

420

0.82 (0.01)

485

1.81 (0.02)

417

1.78 (0.03)

420

1.66 (0.01)

 

22

22

2.70 (0.21)f

22

0.83 (0.05)f

25

2.13 (0.09)

22

1.78 (0.12)g

22

1.75 (0.07)f

rs5167

11

1,147

3.13 (0.03)

1,149

0.87 (0.01)

1,376

1.87 (0.01)

1,137

1.65 (0.02)

1,149

1.60 (0.01)

 

12

974

3.07 (0.03)

975

0.86 (0.01)

1,113

1.82 (0.01)

970

1.74 (0.02)

975

1.66 (0.01)

 

22

235

3.02 (0.06)

235

0.83 (0.02)

273

1.84 (0.03)

233

1.79 (0.04)f

235

1.68 (0.02)f

rs5127

11

1,364

3.12 (0.03)

1,366

0.87 (0.01)

1,621

1.87 (0.01)

1,353

1.67 (0.02)

1,366

1.61 (0.01)

 

12

860

3.05 (0.03)

861

0.85 (0.01)

981

1.80 (0.01)

857

1.75 (0.02)

861

1.66 (0.01)

 

22

132

3.06 (0.09)

132

0.83 (0.02)

160

1.91 (0.03)

130

1.77 (0.05)f

132

1.67 (0.03)f

rs10413089

11

1,616

3.12 (0.02)

1,618

0.86 (0.01)

1,936

1.84 (0.01)

1,605

1.70 (0.01)

1,618

1.62 (0.01)

 

12

660

3.04 (0.04)

661

0.86 (0.01)

735

1.85 (0.02)

657

1.73 (0.02)

661

1.65 (0.01)

 

22

80

2.98 (0.11)

80

0.87 (0.03)

91

2.03 (0.05)

78

1.72 (0.07)

80

1.66 (0.03)

  1. aAverage of available annual measures during the study.
  2. bn, Sample size.
  3. cPvalue adjusted for age and clinic.
  4. dε2 Data shown in light gray
  5. eε4 Data shown in dark gray
  6. fP< 0.01. gP< 0.05.