APOE/C1/C4/C2 Gene Cluster Genotypes, Haplotypes and Lipid Levels in Prospective Coronary Heart Disease Risk Among UK Healthy Men

Table 3 Multivariate regression with stepwise analysis with Akaike′s information criterion (AIC) of the independent contributions of genotype and covariates to lipid traits.

	LDL-C		apoB		TG		HDL-C		apoAI
	Partial		Partial		Partial		Partial		Partial
	(R²× 100)	P value	(R² × 100)	P value	(R² × 100)	P value	(R² × 100)	P value	(R² × 100)	P value
Age	0.00	0.993	0.00	0.798	0.00	0.336	0.00	0.584	0.00	0.584
Clinic	4.32	<0.001	16.16	<0.001	3.76	<0.001	4.32	<0.001	8.76	<0.001
BMI	0.86	<0.001	2.07	<0.001	10.11	<0.001	5.59	<0.001	1.87	<0.001
Smoking	0.01	0.633	0.23	0.010	0.67	<0.001	0.68	<0.001	0.31	<0.001
APOE	3.35	<0.001	3.42	<0.001	0.13	0.020	0.13	0.999	0.37	0.050
rs405509	—	—	—	—	—	—	—	—	0.08	0.111
rs439401	0.52	<0.001	0.62	0.013	—	—	—	—	—	—
rs4420638	0.27	0.009	0.21	0.011	0.05	0.198	—	—	—	—
rs4803770	0.23	0.016	0.22	<0.001	—	—	0.25	0.012	0.23	0.012
rs7259004	—	—	—	—	—	—	0.16	0.045	—	—
rs5167	0.19	0.030	—	—	—	—	0.78	<0.001	0.87	<0.001
rs5127	—	—	0.21	0.013	—	—	—	—	—	—
rs10413089	—	—	—	—	—	—	—	—	0.18	0.193
Genotype R²	4.56		4.68		0.18		1.32		1.56
Total R²	9.08		22.57		14.31		11.29		12.14

ISSN: 1528-3658