Table 5 Cox proportional hazards models for the association between APOE/C1/C4/C2genotypes and risk for CHD event.

APOE

33

1423 (58.2)

161 (60.8)

1 (Ref.^d)

1 (Ref.)

1 (Ref.)

2+^e

401 (16.4)

28 (10.6)

0.63 (0.42–0.95)^f

0.62 (0.41–0.92)^f

0.65 (0.43–0.98)^f

4+^g

621 (25.4)

76 (28.7)

1.02 (0.77–1.34)

1.02 (0.77–1.34)

1.03 (0.78–1.35)

rs405509

11

666 (26.7)

59 (21.5)

1 (Ref.)

1 (Ref.)

1 (Ref.)

12

1318 (52.9)

157 (51.1)

1.28 (0.95–1.73)

1.32 (0.98–1.78)

1.29 (0.95–1.75)

22

508 (20.4)

59 (21.5)

1.28 (0.89–1.84)

1.36 (0.95–1.96)

1.33 (0.92–1.92)

rs439401

11

1056 (42.4)

123 (44.7)

1 (Ref.)

1 (Ref.)

1 (Ref.)

12

1162 (46.6)

121 (44.0)

0.92 (0.72–1.19)

0.95 (0.74–1.23)

0.97 (0.75–1.26)

22

274 (11.0)

31 (11.3)

1.01 (0.68–1.50)

1.05 (0.71–1.56)

1.04 (0.70–1.54)

rs4420638

11

1660 (66.6)

178 (64.7)

1 (Ref.)

1 (Ref.)

1 (Ref.)

12 + 22

832 (33.4)

97 (35.3)

1.02 (0.80–1.31)

1.01 (0.79–1.30)

0.99 (0.77–1.27)

rs4803770

11

887 (35.6)

76 (27.6)

1 (Ref.)

1 (Ref.)

1 (Ref.)

12 + 22

1605 (64.4)

199 (72.4)

1.42 (1.09–1.85)^h

1.38 (1.06–1.80)^f

1.36 (1.04–1.78)^f

rs7259004

11

2025 (81.3)

232 (84.4)

1 (Ref.)

1 (Ref.)

1 (Ref.)

12 + 22

467 (18.7)

43 (15.6)

0.84 (0.60–1.16)

0.81 (0.59–1.13)

0.85 (0.61–1.19)

rs5167

11

1224 (49.1)

157 (57.1)

1 (Ref.)

1 (Ref.)

1 (Ref.)

12

1017 (40.8)

96 (34.9)

0.76 (0.59–0.98)

0.76 (0.59–0.98)

0.78 (0.61–1.02)

22

251 (10.1)

22 (8.0)

0.72 (0.46–1.13)

0.68 (0.44–1.07)

0.73 (0.47–1.15)

rs5127

11

1443 (57.9)

183 (66.6)

1 (Ref.)

1 (Ref.)

1 (Ref.)

12 + 22

1049 (42.1)

92 (33.5)

0.71 (0.55–0.91)^h

0.70 (0.54–0.90)^h

0.72 (0.56–0.93)^f

rs10413089

11

1755 (70.4)

186 (67.6)

1 (Ref.)

1 (Ref.)

1 (Ref.)

12 + 22

734 (29.6)

89 (32.4)

1.17 (0.91–1.51)

1.15 (0.89–1.49)

1.15 (0.89–1.49)