Table 6 Cox proportional hazards models between inferred common haplotypes, using different SNPs from the APOE/C1/C2/C4gene cluster, and CHD events. The reference level is noncarriers of the haplotypes.

C1 (ε3)

1

1

1

1

36.46

34.36

0.91 (0.76–1.09)

0.93 (0.78–1.11)

0.92 (0.77–1.10)

C2 (ε3)

1

1

2

1

25.94

31.27

1.28 (1.07–1.53)^d

1.25 (1.04-1.50)^d

1.24 (1.03-1.49)^d

C3 (ε3)

1

1

2

2

9.72

7.82

0.83 (0.61–1.14)

0.84 (0.61–1.15)

0.84 (0.62–1.15)

C4 (ε4)^e

2

1

1

1

8.51

10.73

1.25 (0.95–1.64)

1.31 (1.00–1.72)

1.29 (0.99–1.70)

C5 (ε4)^e

2

1

1

2

5.56

5.45

0.91 (0.63–1.32)

0.85 (0.59–1.24)

0.82 (0.56–1.20)

C6 (ε2)^f

1

2

1

1

5.06

4.36

0.85 (0.57–1.29)

0.86 (0.57–1.29)

0.85 (0.55–1.30)

C7 (ε3)

1

1

1

2

4.96

3.82

0.80 (0.52–1.24)

0.81 (0.53–1.26)

0.83 (0.54–1.29)

C8 (ε2)^f

1

2

1

2

3.79

2.18

0.61 (0.35–1.09)

0.58 (0.33–1.03)

0.68 (0.38–1.21)

Only C2

11^g

54.01

45.09

Ref.

Ref.

Ref.

12^h

40.33

47.27

1.37 (1.15–1.63)

1.31 (1.10–1.56)ⁱ

1.29 (1.08–1.54)

5.66

7.64

1.63 (1.17–2.26)

1.64 (1.18–2.27)ⁱ

1.54 (1.11–2.15)

Only C4

11

83.71

78.91

Ref.

Ref.

Ref.

12 + 22

16.29

21.09

1.32 (1.07–1.62)ⁱ

1.39 (1.13–1.72)ⁱ

1.38 (1.12–1.70)ⁱ