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Table 3 Median mRNA levels (and ranges) of 15 genes and 2 microRNAs in the 1.4-Mb deletion in dermal and plexiform neurofibromas and MPNSTs.

From: Identification of Genes Potentially Involved in the Increased Risk of Malignancy in NF1-Microdeleted Patients

Genes

Alternative symbols

Dermal neurofibromas (n = 23)

Plexiform neurofibromas (n = 13)

MPNSTs (n = 13)

P a

P b

LRRC37B2

DKFZp667M2411

1.00 (0.54–1.90)

1.16 (0.49–2.71)

1.22 (0.47–1.89)

NS

NSc

CRLF3

CYTOR4

1.00 (0.42–1.88)

1.25 (0.66–1.97)

0.76 (0.17–2.32)

NS

NS

ATAD5

FLJ12735

1.00 (0.38–2.52)

1.19 (0.65–1.62)

3.02 (0.44–9.55)

NS

1.4 × 10−4

C17orf42

FLJ22729

1.00 (0.62–1.79)

1.24 (0.53–3.63)

1.14 (0.27–2.71)

NS

NS

CENTA2

HSA272195

1.00 (0.62–2.27)

0.95 (0.53–4.59)

0.38 (0.15–1.89)

NS

0.014

RNF135

MGC13061

1.00 (0.41–1.68)

0.92 (0.57–1.37)

0.49 (0.13–1.74)

NS

0.026

NF1

1.00 (0.81–1.27)

1.01 (0.49–1.84)

0.93 (0.38–2.25)

NS

NS

OMG

OMGP

1.00 (0.52–1.57)

1.65 (0.51–3.09)

0.92 (0.32–2.16)

0.013

NS

EVI2B

1.00 (0.54–1.75)

0.74 (0.59–1.82)

0.30 (0.14–1.47)

NS

6 × 10−4

EVI2A

1.00 (0.46–1.94)

1.10 (0.46–3.16)

2.03 (0.44–6.93)

NS

0.047

RAB11FIP4

Rab11-FIP4

1.00 (0.37–4.12)

1.23 (0.47–3.23)

0.99 (0.23–5.07)

NS

NS

MIRN193A

hsa-mir-193a

1.00 (0.64–1.48)

0.65 (0.38–1.35)

0.77 (0.40–2.83)

NS

NS

MIRN365-2

hsa-mir-365-2

1.00 (0.55–1.95)

1.49 (0.77–2.35)

0.84 (0.44–1.89)

NS

NS

C17orf79

HSA272196

1.00 (0.35–1.89)

0.95 (0.18–1.69)

2.58 (0.86–4.53)

NS

0.006

UTP6

HCA66, C17orf40

1.00 (0.38–1.51)

1.09 (0.57–1.71)

0.83 (0.32–2.51)

NS

NS

SUZ12

JJAZ1, KIAA0160

1.00 (0.47–1.81)

1.90 (1.02–3.83)

0.96 (0.31–3.31)

2 × 10−4

NS

LRRC37B

LOC114659

1.00 (0.10–2.07)

0.83 (0.16–1.62)

0.94 (0.54–1.96)

NS

NS

MKI67

 

1.00 (0.30–2.82)

1.54 (0.88–4.77)

30.7 (13.6–82.9)

0.012

8 × 10−6

  1. Data are median (range) mRNA levels, unless otherwise indicated. Bold data indicate significantly different expression.
  2. aMann-Whitney U test: plexiform neurofibromas versus dermal neurofibromas.
  3. bMann-Whitney U test: MPNSTs versus dermal neurofibromas.
  4. cNS, not significant.