Skip to main content
Figure 3 | Molecular Medicine

Figure 3

From: Peripheral Administration of Human Adrenomedullin and Its Binding Protein Attenuates Stroke-Induced Apoptosis and Brain Injury in Rats

Figure 3

Effects of human AM/AMBP-1 on the size of brain infarct after stroke. (A) The volume of ischemic brain infarct in sham-operated animals (Sham) and stroke animals treated with human albumin (Vehicle), human AM/AMBP-1 (AM/AMBP-1), human AM alone (AM) or human AMBP-1 alone (AMBP-1) at 24 h after permanent MCAO. (B) The volume of ischemic brain infarct in sham-operated animals (Sham) and stroke animals treated with human albumin (Vehicle) or human AM/AMBP-1 (AM/AMBP-1) at 72 h after permanent MCAO. Data are means ± SE (n = 5–6/group) and compared by one-way ANOVA and Student-Newman-Keul test: *P < 0.05 versus sham group; #P < 0.05 versus vehicle group. Representative triphenyl tetrazolium chloride staining of coronal sections at the bregma level were presented. Note area of the infarct (white) was significantly smaller in animals treated with human AM/AMBP-1 after permanent MCAO. However, AM or AMBP-1 alone had no effect on the infarct volume after stroke.

Back to article page

Molecular Medicine

ISSN: 1528-3658