Table 1 Potential positive and negative aspects of visfatin action in CHC.
Potential negative action | Potential positive action |
|---|---|
Increase of TNFα production | Improvement of insulin sensitivity |
Stimulation of VCAM-1 synthesis | Increase of glucose uptake |
Increase of ICAM-1 synthesis | Decrease of glucose release from hepatocytes |
Enhancement of monocytes | |
Stimulation of transmigration and adhesion of macrophages | Increase of MMPs synthesis and activity Inhibition of TIMP synthesis and activity |
Activation of NF-κB | Increase of PPARy expression and decrease of serum cholesterol level |
Upregulation of reactive oxygen species | |
Increase of IL-1 β synthesis | Inhibition of hepatocyte apoptosis |
Stimulation of HCC development | Regulation of NAD synthesis |
Enhancement of angiogenesis; increase of VEGF synthesis and activity; increase of VEGF-R2 expression | Activation of sirtuin-1 |
Increase of IL-6 synthesis | |