Table 2 Potential positive and negative aspects of chemerin action in CHC.
Potential negative action | Potential positive action |
|---|---|
Stimulation of transmigration and adhesion of macrophages | Improvement of insulin sensitivity Increase of glucose uptake |
Enhancement of monocytes and dendritic cells | Decrease of glucose release from hepatocytes |
Activation of NF-κB | Increase of MMPs synthesis and activity |
Increase of IL-1β synthesis | Stimulation of IL-10 production |
Enhancement of angiogenesis, increase of VEGF synthesis and activity Upregulation of TGFβ production | Decrease of TNFα production |
Decrease of IL-6 synthesis Activation of NK cells | |