D-Chiro-Inositol Glycans in Insulin Signaling and Insulin Resistance

Table 1 Clamp-study biopsy of myo-inositol and chiro-inositol.^a

Group	Time from start of clamp study to biopsy, min	Myo-inositol concentration, ng/mg net weight of tissue	Chiro-inositol concentration, ng/mg net weight of tissue
Normal subjects	0	0.28 ± 0.11	0.09 ± 0.03
	15	2.58 ± 0.41	0.52 ± 0.14
	20	0.10 ± 0.02	0.03 ± 0.02
NIDDM	0	0.57 ± 0.33	<0.01
	15	6.48 ± 3.10	<0.01
	20	1.32 ± 0.81	<0.01

^aPlus-minus values are mean ± SEM. Four normal subjects and five patients with non-insulin-dependent diabetes mellitus (NIDDM) were studied immediately before the insulin infusion. Samples were obtained 15 min after the beginning of the insulin infusion in two normal subjects and two patients with NIDDM and 20 min after the beginning of the infusion in two normal subjects and three patients with NIDDM (51).

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