|
Cytokines
| | | |
|
TNF−/−; TNF R1/R2−/−
|
Ischemia/reperfusion-induced ALI
|
Not protective
|
(96)
|
|
IL-1β+/+
|
Adenoviral gene transfer to transiently overexpress IL-1β in rat lungs after intratracheal administration induces acute lung injury
|
induce ALI
|
(214)
|
|
Chemokines and their receptors
| | | |
|
CXCR2−/−
|
LPS inhalation
|
Protective
|
(82)
|
|
CXCR2−/−
|
Ischemia reperfusion
|
Protective
|
(81)
|
|
CXCR2−/−
|
Ventilator-induced ALI in CXCR2−/− mouse
|
Protective
|
(81)
|
|
IL-1β (Caspase
|
Bleomycin-induced lung injury
|
Protective
|
(97)
|
|
IL-18−/−
|
Bleomycin-induced lung injury
|
Protective
|
(97)
|
|
CCR1−/−
|
Pancreatitis-associated lung Injury
|
Protective
|
(215)
|
|
CXCL5−/− (ENA-78)
|
Intratracheal application of E. coli
|
Protective
|
(86)
|
|
DARC−/−
|
LPS inhalation
|
Not protective
|
(87)
|
|
Cell adhesion molecules
| | | |
|
P-selectin−/−
|
Cobra venom factor (CVF)-induced ALI
|
Not protective
|
(46)
|
|
ICAM-1−/−
|
CVF-induced ALI;
|
Not protective
|
(46)
|
|
Granule proteins
| | | |
|
Neutrophil elastase−/−
|
Intraperitoneal infection with Gram-negative bacteria (Klebsiella pneumoniae and E. coli)
|
Not protective; increased mortality
|
(117)
|
|
Neutrophil elastase−/−
|
Intratracheal application of LPS
|
Not protective, similar recruitment
|
(216)
|
|
Neutrophil elastase−/− and Cathepsin G−/−
|
Endotoxic shock with LPS
|
Decreased mortality and lung injury in comparison to wild type mice
|
(217)
|
|
MMP 8−/−
|
Intratracheal application of LPS
|
Not protective, increased ALI
|
(153)
|
|
MMP 8−/−
|
Ventilator-induced ALI (VILI)
|
Protective
|
(152)
|
|
MMP 9−/−
|
Ozone-induced ALI
|
Not protective, increased ALI
|
(150)
|
|
MMP 9−/−
|
Ventilator-induced ALI (VILI)
|
Not protective, increased ALI
|
(151)
|
|
α-Defensins+/+ (transgenic mice)
|
Using mice transgenic for polymorphonuclear leukocyte expression of α-defensins; acid aspiration-induced ALI
| | |
|
Radical release
| | | |
|
NADPH oxidase−/−
|
Complement-induced ALI
|
not protected
|
(205)
|
|
NADPH oxidase 1−/−NADPH oxidase 2−/−
|
Hyperoxia-induced ALI
|
NADPH protective NADPH 2−/− Not protective
|
(204)
|
|
Nitric oxide synthase−/−
|
LPS-induced ALI
|
Protective
|
(207)
|
