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Table 1 Frequency of high- and low-affinity DNA-reactive B cells in WT, ERα-deficient, and ERβ-deficient R4A-Tg mice treated with P or E2.a

From: Differential Roles of Estrogen Receptors α and β in Control of B-Cell Maturation and Selection

 

WT

ERβ-/-

ERα-/-

 

P

E2

P

E2

P

E2

High-affinity

3/48 (6.3%)

14/54 (26%)b

6/58 (10%)

22/65 (33%)b

7/62 (11%)

14/70 (20%)

Low-affinity

7/48 (18%)

6/54 (11%)

6/58 (10%)

7/65 (11%)

8/62 (13%)

8/70 (9%)

  1. aThe Fisher exact test was performed to compare the frequency of high- and low-affinity DNA-reactive mature B cells between E2-treated and P-treated R4A-Tg WT, R4A-Tg ERβ-deficient, and R4A-Tg ERα-deficient mice.
  2. bP < 0.05 (P value signifies a difference between P-treated and E2-treated mice).
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Molecular Medicine

ISSN: 1528-3658