Figure 5
From: S1P Is Associated with Protection in Human and Experimental Cerebral Malaria
FTY720 treatment of ECM decreases lymphocyte numbers and granzyme A mRNA in the brain. (A) Relative CD8+ and (B) CD4+ T-cell numbers isolated from the brains of mice infected for 6 d. Numbers were decreased in animals treated with FTY720 1 d before infection and 1 d p.i. (CD4+: P < 0.5 and P < 0.001, CD8+: P < 0.5 and P < 0.01 respectively, KW and DMC, two pooled IE, n ≥ 4/group/IE) (C) GZMA mRNA levels were decreased in the brains of FTY720-treated animals compared with control animals: for (FTY720 (−1), P < 0.05, FTY720 (+1) P > 0.05 and FTY720 (+3), P < 0.01; KW and DMC, two pooled IE, n ≥ 3/group/IE).