Table 3 List of potential modifier genes with opposite dysregulation in patients with rapid versus slow disease progression.
From: Analysis of Potential Biomarkers and Modifier Genes Affecting the Clinical Course of CLN3 Disease
Fold change | |||
|---|---|---|---|
Gene symbol | Gene name | Rapid | Slow |
KLF6 | Kruppel-like factor 6 | +2.0 | ™1.9 |
MARCKS | Myristoylated alanine-rich protein kinase C substrate | +2.0 | ™1.7 |
LOC283663 | Hypothetical protein LOC283663 | +1.9 | ™1.7 |
BLK | B lymphoid tyrosine kinase | +1.9 | ™2.0 |
FCGR2B/FCGR2C | Fc fragment of IgG, low affinity IIb, receptor (CD32)/Fc fragment of IgG, low affinity IIc, receptor for (CD32) | +1.9 | −2.1 |
SPIB | Spi-B transcription factor (Spi-1/PU. 1 related) | +1.8 | −6.2 |
MS4A1 | Membrane-spanning 4-domains, subfamily A, member 1 | +1.8 | −2.0 |
RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | +1.8 | −1.9 |
ZNF718 | Zinc finger protein 718 | +2.1 | −26.9 |
BACE2 | β-Site APP-cleaving enzyme 2 | +2.1 | −2.8 |
LOC283663 | Hypothetical protein LOC283663 | +2.0 | −1.9 |
GPR109B | G protein-coupled receptor 109B | +1.9 | −3.9 |
CLLU1 | Chronic lymphocytic leukemia upregulated 1 | +1.7 | −4.4 |
FLJ10357 | Protein SOLO | −1.7 | +2.0 |