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Figure 5 | Molecular Medicine

Figure 5

From: Angiotensin-II Mediates Nonmuscle Myosin II Activation and Expression and Contributes to Human Keloid Disease Progression

Figure 5

Representative immunohistological staining of NMM IIA and NMM IIB and AT] and AT2. (B, C) NMM IIA and IIB immunostaining is increased in the periphery of keloids. This is a hypercellular region of dermis densely populated by fibroblasts, with significantly increased NMM IIA and IIB expression in the cytoplasm and perinuclear regions of the dermal fibroblasts. (E, F) In normal, nonkeloidal skin, no staining of dermal fibroblasts was observed for either AT1 or AT2. (G) Staining for AT1 in keloid revealed a heterogeneous distribution of expression within dermal fibroblasts, with the lowest signal observed in regions of fibroblast hypocellularity and highest signal observed in regions of relative fibroblast hypercellularity. (H) No staining for AT2 was observed in dermal fibroblasts of keloids. NMM IIA, NMMIIB, AT1 and AT2 scale bars = 500 µm

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Molecular Medicine

ISSN: 1528-3658