Increased proinflammatory cytokine and chemokine levels in caspase-mice after HS/BFF. IL6, IL12 and MCP-1 are all significantly increased in caspase-mice after HS/BFF compared with WT. KC increases in both WT and caspase-1−/− mice after HS/BFF, but is not different between the mouse strains. n = 3–6/group; data show mean ± SEM; *P < 0.05 WT versus caspase-1−/− HS/BFF; #P < 0.05 versus control; +P < 0.05 versus sham. ND, not detected.