Figure 1
From: Histone Deacetylase (HDAC) Inhibition as a Novel Treatment for Diabetes Mellitus
Model of changes in acetylation levels in pancreatic β cells of IUGR. (A) Under normal conditions, the Pdxl proximal promoter is associated with acetylated nucleosomes (Ac, green squares) (B) During IUGR, a complex containing HDAC1 and Sin3A induces a progressive loss of histone acetylation in islets from fetal and 2-week-old mice. This then leads to repression of Pdxl expression. (C) This effect is reversed by HDAC inhibition. Simplified from Park et al. (38).