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Table 2 B-cell phenotype distribution in PB and SF in AB+ and AB− RA and no-RA patients.

From: B-Cell Subsets in the Joint Compartments of Seropositive and Seronegative Rheumatoid Arthritis (RA) and No-RA Arthritides Express Memory Markers and ZAP70 and Characterize the Aggregate Pattern Irrespectively of the Autoantibody Status

B-cell subpopulation (flow cytometry) RA patients, AB+, n = 14 RA patients, AB−, n = 13 P No-RA patients, n = 13 P a P b
PB       
WBC count (n/μL) 8,428 ± 3,146 8,363 ± 2,876 0.87 7,061 ± 2,037 0.21 0.23
Lymphocytes (%) 32.7 ± 12.4 28.8 ± 12.8 0.51 27.8 ± 11.1 0.48 0.71
Lymphocytes (n/μL) 2,760 ± 1,160 2,082 ± 651 0.06 2,038 ± 1,002 0.13 0.71
CD19 (%) 7.8 ± 4.5 8.4 ± 5.2 0.83 7.9 ± 4.5 0.85 0.82
Bml (%) 31.3 ± 12.1 25.3 ± 15.4 0.25 17.3 ± 6.7 0.08 0.32
Bm2+Bm2′ (%) 28.1 ± 20.6 35.1 ± 19.3 0.57 48.4 ± 6.2 0.11 0.25
eBm5 (%) 11.2 ± 4.8 15.8 ± 8.8 0.48 15.7 ± 6.3 0.20 1.00
Bm5 (%) 24.7 ± 22.3 20.0 ± 16.7 0.89 16.1 ± 11.0 1.00 0.57
Ratio Bm2+Bm2′/ 2.3 ± 3.1 1.4 ± 1.0 0.89 1.6 ± 0.6 0.75 0.89
eBm5+Bm5       
IgD+/CD27− (%) 49.4 ± 24.6 49.7 ± 21.4 0.89 62.5 ± 6.0 0.75 0.39
IgD+/CD27+ (%) 11.5 ± 6.8 14.2 ± 14.2 0.67 5.7 ± 3.8 0.05 0.25
IgD−/CD27+ (%) 24.6 ± 15.4 23.2 ± 17.0 0.89 14.4 ± 6.7 0.26 0.39
IgD−/CD27− (%) 14.3 ± 8.8 12.9 ± 5.6 0.89 17.4 ± 9.8 0.63 0.74
CD19+/ 8.2 ± 3.8 11.6 ± 9.9 0.67 8.0 ± 4.4 1.00 0.67
CD27+CD38+ (%)       
CD19+/ZAP70+(%) 7.6 ± 6.9 6.6 ± 4.6 1.00 4.0 ± 2.8 0.46 0.25
SF       
WBC count (n/μL) 14,480 ± 12,375 13,150 ± 13,085 0.67 14,920 ± 10,656 0.71 0.58
Lymphocytes (%) 26.4 ± 19.0 13.1 ± 9.1 0.07 19.4 ± 12.2 0.34 0.20
Lymphocytes (n/μL) 2,213 ± 1,609 1,092 ± 857 0.08 1,878 ± 1,278 0.58 0.14
CD19 (%) 2.2 ± 3.0 0.8 ± 0.5 0.14 0.6 ± 0.8 0.02 0.16
Bm1 (%) 25.7 ± 32.8 17.5 ± 11.1 0.67 12.2 ± 5.7 0.43 0.34
Bm2+Bm2′(%) 2.2 ± 0.8 5.0 ± 4.4 0.20 2.1 ± 1.0 0.93 0.15
eBm5 (%) 14.1 ± 11.2 14.8 ± 8.5 0.62 15.2 ± 12.3 0.62 0.75
Bm5 (%) 53.1 ± 28.6 60.4 ± 8.2 1.00 68.7 ± 14.6 0.35 0.34
Ratio Bm2+Bm2′/ 0.03 ± 0.01 0.07 ± 0.06 0.14 0.03 ± 0.01 0.65 0.15
eBm5+Bm5       
IgD+/CD27− (%) 19.7 ± 18.3 17.6 ± 6.8 0.78 11.0 ± 3.4 0.52 0.05
IgD+/CD27+ (%) 9.0 ± 15.2 7.8 ± 8.0 0.48 6.3 ± 4.5 0.52 0.87
IgD−/CD27+ (%) 53.7 ± 12.1 51.4 ± 17.3 1.00 60.9 ± 5.4 0.41 0.52
IgD−/CD27− (%) 30.7 ± 16.6 23.2 ± 11.8 0.15 21.8 ± 8.6 0.22 0.69
CD19+/       
CD27+CD38+ (%) 7.6 ± 7.3 8.5 ± 7.1 0.89 10.0 ± 7.9 0.43 0.75
CD19+/ZAP70+(%) 28.5 ± 27.5 20.9 ± 12.6 0.96 22.2 ± 12.6 0.96 0.83
  1. Data are means ± SD. Kruskal-Wallis test: no significant differences between RA AB+, RA AB− and no-RA patients.
  2. aMann-Whitney test between RA AB+ and no-RA patients.
  3. bMann-Whitney test between RA AB− and no-RA patients.
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Molecular Medicine

ISSN: 1528-3658