Skip to main content

Table 2 The association between SNP rs11066001 in BRAP and carotid atherosclerosis.

From: BRAP Activates Inflammatory Cascades and Increases the Risk for Carotid Atherosclerosis

Phenotype   Genotype   Statistics (recessive model)
Carotid plaque AA AG GG Logistic regressiona
Absence 563 (50.6%) 472 (42.4%) 77 (6.9%) Reference
Presence 278 (48.9%) 235 (41.3%) 56 (9.8%) OR = 1.58 (1.08–2.34);
     P = 0.021
Carotid IMT     
Continuous IMT data AA (n = 700) AG (n = 571) GG (n = 100) Multivariate regressiona
CCA, mean ± SD, mm 0.62 ± 0.14 0.63 ± 0.14 0.65 ± 0.16 P = 0.089
Bif, mean ± SD, mm 0.65 ± 0.13 0.66 ± 0.13 0.66 ± 0.13 P = 0.732
ICA, mean ± SD, mm 0.51 ± 0.10 0.51 ± 0.09 0.51 ± 0.10 P = 0.834
Dichotomized IMT, ≥mean + 1 SD versus < mean + 1 SD     Logistic regressiona
CCA 46.0% 43.1% 10.9% OR = 2.25 (1.30–3.89),
  versus 52.0% versus 41.4% versus 6.6% P = 0.004
Bif 49.0% 43.7% 7.3% OR = 1.12 (0.61–2.03),
  versus 51.5% versus 41.2% versus 7.3% P = 0.720
ICA 54.5% 39.6% 5.9% OR = 0.77 (0.40–1.50);
  versus 50.5% versus 42.0% versus 7.5% P = 0.445
  1. aP value obtained from multivariate regression analysis with adjustment for age, sex, hypertension, diabetes, hyperlipidemia, BMI and smoking. Only covariates with P< 0.05 were kept in the regression models.