Figure 1From: Low-Dose Methotrexate Inhibits Methionine S-Adenosyltransferase In Vitro and In VivoS-adenosylmethionine (AdoMet) levels were highly correlated with the intracellular folate levels in HepG2 cells (r = 0.947, P < 0.001, n = 12). Control (●): cultured in α-MEM. FA def (): folate restricted (10 nmol/L) for 144 h. MTX (●): treated with 50 nmol/L MTX for 72 h (n = 3 in each treatment).Back to article page