Figure 4
From: Low-Dose Methotrexate Inhibits Methionine S-Adenosyltransferase In Vitro and In Vivo
Effect of MTX treatments on MAT expression and enzyme activity in HepG2 cells. (A) MAT2A mRNA. (B) MAT II protein. (C) MAT enzyme activity. Data are shown as mean ± standard error (SE). MAT2A mRNA and protein were significantly decreased in MTX-treated cells at 72 h (P < 0.05). MAT activity was inhibited by 33%, 52%, and 61% at 24 h, 48 h and 72 h, respectively (P ≤ 0.001).