Figure 5From: Low-Dose Methotrexate Inhibits Methionine S-Adenosyltransferase In Vitro and In VivoMTX treatment significantly reduced MAT expression and enzyme activity in vivo. (A) mRNA expression. MAT1A (from the liver) and MAT2A (from the kidney). (B) MAT I/III protein (liver) and MAT II (kidney) expressions, and (C) MAT enzyme activities. Data are shown as mean ± SE. Controls are shown in filled bar and MTX in open bar (n = 5–6 per group).Back to article page