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Figure 3 | Molecular Medicine

Figure 3

From: Inhibition of HDAC Activity by ITF2357 Ameliorates Joint Inflammation and Prevents Cartilage and Bone Destruction in Experimental Arthritis

Figure 3

IL-1β- or TNFα-induced bone resorption is inhibited by ITF2357. (A) IL-1β-induced Ca-release using the standard mouse calvaria assay. Bone resorption assay (calcium release in 48 h) from 5-day-old mouse calvaria (n = 5 per group). ITF2357 was added in a dose-range from 0 up to 1 µM. PGE2 served as positive control. IL-1β at 5ng/mL. (B) Identical for TNFα-induced bone resorption. TNFα at 1 µg/mL. Mann-Whitney U test was used for statistical analysis. *P < 0.001.

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Molecular Medicine

ISSN: 1528-3658