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Table 2 Histopathology evaluation of the effect of givinostat administration (10 mg/kg) on joint inflammation and tissue damages in the CIA model at day 28.

From: Inhibition of HDAC Activity by ITF2357 Ameliorates Joint Inflammation and Prevents Cartilage and Bone Destruction in Experimental Arthritis

Treatment

Periarticular score

Bone and cartilage damage

Dilatation of joint cavity

Necrotic and inflammatory deposits in the joint cavity

Vehicle

2.08

1.50

1.25

1.75

Prophylactic

0.75

0.67

0.58

0.58

Therapeutic

0.83

0.42

0.33

0.50

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Molecular Medicine

ISSN: 1528-3658