Figure 5

Changes in renal cortical immunolocalization of collagen type I and type IV and collagen levels in WT and TRPV1^−/− mice after 4 wks of deoxycorticosterone acetate (DOCA)-salt treatment. (A, B) Representative immunostained kidney sections showing the immunostaining of collagen type I and type IV (in red) in control WT and TRPV1^−/− mice (a and b), and WT and TRPV1^−/− mice (c and d) treated with DOCA-salt. Arrows point to collagen type I-positive staining (A) or collagen type IV-positive staining (B). Magnification, 400×. (C) Bar graph shows the changes in renal collagen levels in WT and TRPV1^−/− mice with or without DOCA-salt treatment. Values are mean ± SE (n = 7 to 8). *P < 0.05 compared to control WT or TRPV1^−/− mice; ^†P < 0.05 compared to DOCA-WT mice.