Figure 9

Changes in renal phosphorylated Smad2 (pSmad2) and phosphorylated Smad3 (pSmad3) protein expression in WT and TRPV1^−/− mice after 4 wks of deoxycorticosterone acetate (DOCA)-salt treatment. (A, C) Representative Western blot of renal pSmad2 (A) and pSmad3 (C) in WT and TRPV1^−/− mice with or without DOCA-salt treatment. (B, D) Bar graphs show the relative optical density values for renal pSmad2 (B) and pSmad3 (D) in WT and TRPV1^−/− mice with or without DOCA-salt treatment. Results were expressed as ratio of pSmad2 and pSmad3 to corresponding β-actin. Values are mean ± SE (n = 4 to 5). *P < 0.05 compared to control WT or TRPV1^−/− mice; ^†P < 0.05 compared to DOCA-WT mice.