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Table 1 AP characteristics of cardiac myocytes in WT and M3-overexpressing (M3Tg) mice from both control and myocardial I/R injury.

From: Overexpression of M3 Muscarinic Receptor Is a Novel Strategy for Preventing Sudden Cardiac Death in Transgenic Mice

Group

na

RMP (mV)

Overshoot (mV)

Amplitude of action (mV)

APD (ms)

WT

6

−54.3 ± 0.8

40.9 ± 3.2

95.3 ± 3.7

182.7 ± 16.0

M3Tg

6

−63.3 ± 1.5b

40.7 ± 3.1

104.1 ± 3.4

130.2 ± 16.7c

WT I/R

14

−54.5 ± 0.9

32.1 ± 2.6

86.7 ± 3.5

161.1 ± 10.4

M3Tg I/R

14

−56.1 ± 1.2

34.8 ± 2.6

90.9 ± 3.5

131.6 ± 7.9d

  1. Data are mean ± SEM.
  2. aThe number of cardiac myocytes.
  3. bP < 0.01, cP < 0.05 versus WT group.
  4. dP < 0.05 versus WT I/R group.
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Molecular Medicine

ISSN: 1528-3658