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Figure 5 | Molecular Medicine

Figure 5

From: Tetrahydrobiopterin, L-Arginine and Vitamin C Act Synergistically to Decrease Oxidant Stress and Increase Nitric Oxide That Increases Blood Flow Recovery after Hindlimb Ischemia in the Rat

Figure 5

Effects of BH4, L-arginine (L-arg) and vitamin C (VitC) on collateral enlargement after induction of hindlimb ischemia. (A) The angioscore, determined 42 d after the induction of hindlimb ischemia and calculated as described in the text, was greater in rats receiving BH4 + L-arginine or BH4 + L-arginine + vitamin C than in all other groups. Data are means ± sd; n = 6. *p < 0.05 for BH4 + L-arginine or BH4 + L-arginine + vitamin C groups versus all other groups. (B) Representative angiogram from each study group. (C) Greater collateral artery diameters were observed in rats receiving BH4 + L-arginine; addition of vitamin C further increased collateral diameter. Data are means ± sd; n = 6. *p < 0.05 for BH4 + L-arginine or BH4 + L-arginine + vitamin C groups versus all other groups; ‡p < 0.05 versus BH4 + L-arginine group. (D) Representative images for collateral diameter.

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Molecular Medicine

ISSN: 1528-3658