Skip to main content
Figure 4 | Molecular Medicine

Figure 4

From: Tetrahydrobiopterin, L-Arginine and Vitamin C Act Synergistically to Decrease Oxidative Stress, Increase Nitric Oxide and Improve Blood Flow after Induction of Hindlimb Ischemia in the Rat

Figure 4

Effects of BH4, L-arginine and vitamin C on perfusion recovery after induction of hindlimb ischemia. (A) Laser Doppler perfusion imaging (LDPI) data, expressed as the ratio of blood flow from the ischemic to nonischemic hindlimbs, was determined before, immediately after and then serially over the ensuing 6 wks. Group identity is shown in the color key. Data are mean ± sd; n = 6. *p < 0.05 for BH4 + L-arginine or BH4 + L-arginine + vitamin C groups versus all other groups. (B) The angioscore, determined 42 d after the induction of hindlimb ischemia and calculated as described in the text, was greater in rats receiving BH4 + L-arginine or BH4 + L-arginine + vitamin C than in all other groups. Data are mean ± sd; n = 6. *p < 0.05 for BH4 + L-arginine or BH4 + L-arginine + vitamin C groups versus all other groups. (C) Representative angiogram from each study group.

Back to article page

Molecular Medicine

ISSN: 1528-3658