Figure 7

Schematic summarizing of mutation frequency concordance and chemical features of R mutations in paired IGHV and IGK/LV of mutated CLL clones. The different findings obtained from the analysis of the correlation of mutations and from the analysis of trait conservation for the paired IGHV and IGK/LV of the CLL cohort are shown. The left column summarizes the data shown in Figure 1 and indicates concordance (yes) or not (no) in the number of R mutations in paired IGHVs and IGK/LVs. The central column summarizes data presented in Figures 4A and 5 and displays the presence or absence of R mutation concordance as well as the comparison of diversification features generated by R mutations in IGHV and IGK/LV segments. The right column summarizes the data in Figure 4B and displays concordance of S mutations between paired IGHV and IGK/LV.