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Table 1 Clinical and pathological data of patient-derived xenografts.

From: In Vivo Topoisomerase I Inhibition Attenuates the Expression of Hypoxia-Inducible Factor 1α Target Genes and Decreases Tumor Angiogenesis

Xenografts

2

17

21

22

36 T, 36 M1, and 36 M3

TNM

pT2N0M0

pT3N1M0

pT2N1M0

pT2N2M1

pT3N2M1

Stage

I

III

III

IV

IV

Tumor localization

Right colon

Right colon

Left colon

Right colon

Left colon

Metastasis localization

NA

NA

NA

Liver and lung

Synchronous liver metastases

Sex

M

M

F

M

M

Age (years)

72

77

57

63

74

Treatment after surgery

0

0

FUFOL

FOLFIRI

FOLFOX

Evolution

No recurrence. Death from hepatocellular carcinoma.

No recurrence. Death from cholangiocarcinoma.

Lung metastasis and lateroaortic adenopathy 2 years after surgery. Still alive 6 years after surgery

Disease progression after 10 months. Death related to cancer 2 years after surgery.

Disease progression after 4 months. Death related to cancer 2 years after surgery.

  1. NA, nonapplicable.