Figure 4

Clinical outcome and histopathology of human SkmSC-trasplanted Wr mice. (A–C) Behavioral scores of Wr mice that received human SkmSCs or vehicle. Each point represents the mean ± SD of 15 animals per group. , Wobbler PBS;Wobbler SkmSCs. (D, E) Representative immunohistochemistry of ChAT-positive motor neurons in cervical spinal cord from 9-wk-old healthy mice (D) and from age-matched Wr mice (E); scale = 100 [xm. (D′ and E′) Representative view of biceps muscle fibers in both healthy (D′) and Wr mice (E′); scale = 25 [xm. Bromo indoxyl acetate (blue). (F–H) Histograms showing the values of ChAT-positive motor neurons and active neuromuscular junctions. Data represent mean ± SD of 14 replications. *P< 0.05; **P < 0.01; ***P < 0.0001; ^∧∧∧p< 0.0001. Q36. CTR, Control healthy mice.